FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rhounspecified
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General Information
Symbol
Dmel\rhounspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0050939
Feature type
allele
Associated gene
Dmel\rho
Associated Insertion(s)
Carried in Construct
Also Known As
veunspecified, unspecified
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants show defects in the axon pattern of class IV dendritic arborization (da) neurons. The axon scaffold has fused longitudinals.

        (Grueber et al., 2007)

        Only 30% of cuticles from rhounspecified homozygous embryos show fusion of at least one pair of denticle belts. The most commonly fused denticle belts are T3/A1, A4/A5 and A5/A6.

        (Urban et al., 2004)

        Somatic clones of rho null mutants cause no defects in cell recruitment in the eye. Indeed in clones generated using the Minute technique, entire rho- eyes are found to be phenotypically wild-type.

        (Wasserman et al., 2000)

        Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons.

        (Hummel et al., 1999)

        Causes breaks and deletions mostly in the longitudinal dorsal trunks of the embryonic tracheal system. Not all tracheal migration is impaired.

        (Llimargas and Casanova, 1997)

        Flies are flightless, although they attempt flight, performing both jumping, wing raising and wing lowering, but the wing-beat cycle is not initiated.

        (Sparrow, 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Suppressed by
        Enhancer of
        Suppressor of
        Statement
        Reference

        rhounspecified/rhounspecified is a suppressor of phenotype of EgfrE3

        (Diaz-Benjumea and Garcia-Bellido, 1990)
        NOT Suppressor of
        Statement
        Reference

        rhounspecified is a non-suppressor of somatic muscle cell | ectopic | embryonic stage phenotype of Scer\GAL469B, vnUAS.cYa

        (Yarnitzky et al., 1998)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        2/3 of vn10567; rhounspecified double homozygous embryo cuticles show a general loss of cuticle integrity. Of the remaining 1/3 of cuticles the percentage with >2 denticle belt fusions is increased from <10% for rhounspecified to >30%. (Note, while the authors do not name an rho allele for this analysis, they do claim to have used a null allele.)

        (Urban et al., 2004)

        salm3 rhounspecified double mutant embryos lack all oenocytes. The number of chordotonal organs in the lch5 cluster is reduced from 5 to 3, as is seen in rhounspecified single mutants.

        (Elstob et al., 2001)

        Does not suppress the production of extra eve-positive muscle precursor clusters seen in embryos expressing vnScer\UAS.cYa under the control of Scer\GAL469B.

        (Yarnitzky et al., 1998)

        Egfrt1/Egfrf11 rhounspecified/rhounspecified double mutants have a superadditive phenotype. EgfrE3/EgfrE3 shows a negative interaction in combination with rhounspecified/rhounspecified. The lack of vein phenotype of rhounspecified vnunspecified flies is partially rescued by EgfrE3/EgfrE3.

        (Diaz-Benjumea and Garcia-Bellido, 1990)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        rhoKG07115

        (Dworkin and Gibson, 2006)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        rhounspecified
        unspecified
        (Sparrow, 1991, Diaz-Benjumea and Garcia-Bellido, 1990)
        veunspecified
        (Hummel et al., 1999, Yarnitzky et al., 1998, Llimargas and Casanova, 1997)
        Name Synonyms
        Secondary FlyBase IDs
        • FBal0035906
        References (14)