FB2026_02 , released June 18, 2026
Allele: Dmel\tkvQ253D.Ubx
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General Information
Symbol
Dmel\tkvQ253D.Ubx
Species
D. melanogaster
Name
FlyBase ID
FBal0051059
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{Ubx(-FRT)tkv.Q253D}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
FLPase
(de Celis, 1997, Lecuit et al., 1996)
Progenitor genotype
tkvQ253D.FRT.Ubx
(Tomoyasu et al., 2000, de Celis, 1997, Lecuit et al., 1996)
Carried in construct
P{Ubx(-FRT)tkv.Q253D}
Cytology
Description

FRT cassette has been excised, juxtaposing Ubx promoter with tkv coding sequences.

(Lecuit et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Ubx
Encoded product / tool
tkv
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant clones show cell autonomous outgrowths similar to those caused by brkM68 clones. Outgrowths are often accompanied by notches. Detailed examination of the outgrowths suggests that loss of brk produces a lower level of activation than that caused by constitutively activated tkv.

      (Jazwinska et al., 1999)

      Scer\FLP1 induced clones of tkvQ253D.Ubx expressing cells result in the formation of ectopic veins.

      (de Celis, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Exists in clones, not reported as being germ-line transmitted.

      (de Celis, 1997, Lecuit et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Tkv*
      (Jazwinska et al., 1999)
      tkvQ253D.Ubx
      tkvUbx.PL
      Name Synonyms
      Secondary FlyBase IDs
        References (4)