FlyBase Allele Report: Dmel\salr[UAS.cBa]

General Information

Symbol

Dmel\salr^UAS.cBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Barrio

FlyBase ID

FBal0051184

Feature type

allele

Associated gene

Dmel\salr

Associated Insertion(s)

Carried in Construct

P{UAS-salr.B}

Also Known As

UAS-salr

Key Links

Transgenic product class

cDNA

(de Celis et al., 1996)

wild_type

(de Celis et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(de Celis et al., 1996)

wild_type

(de Celis et al., 1996)

Mutagen

in vitro construct

(Lunde et al., 1998, de Celis et al., 1996)

Progenitor genotype

Carried in construct

P{UAS-salr.B}

Cytology

Description

UAS regulatory sequences drive expression of an EcoRI salr cDNA fragment.

(de Celis et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

salr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Sun et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is exacerbated by Myc^HMS01538

(Sun et al., 2020)

is ameliorated by Myc^UAS.cZa

(Sun et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage, with Scer\GAL4^phtm.PO

(Ostalé et al., 2024)

visible, with Scer\GAL4^Bx-MS1096

(Lunde et al., 1998)

visible, with Scer\GAL4^C-765

(de Celis and Barrio, 2000, de Celis et al., 1999)

visible, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

Phenotype Manifest In

adult thorax & macrochaeta, with Scer\GAL4^Bx-MS1096

(Lunde et al., 1998)

anterior dorsocentral bristle, with Scer\GAL4^C-765

(de Celis et al., 1999)

anterior dorsocentral bristle, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

anterior notopleural bristle, with Scer\GAL4^C-765

(de Celis et al., 1999)

anterior postalar bristle, with Scer\GAL4^C-765

(de Celis et al., 1999)

anterior postalar bristle | precursor, with Scer\GAL4^C-765

(de Celis et al., 1999)

dorsocentral bristle | precursor, with Scer\GAL4^C-765

(de Celis et al., 1999)

macrochaeta, with Scer\GAL4^C-765

(de Celis et al., 1999)

macrochaeta, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

macrochaeta | ectopic, with Scer\GAL4^C-765

(de Celis et al., 1999)

notopleural bristle | precursor, with Scer\GAL4^C-765

(de Celis et al., 1999)

postalar bristle | precursor, with Scer\GAL4^C-765

(de Celis et al., 1999)

posterior dorsocentral bristle, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

posterior notopleural bristle, with Scer\GAL4^C-765

(de Celis et al., 1999)

posterior postalar bristle, with Scer\GAL4^C-765

(de Celis et al., 1999)

posterior postalar bristle, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

posterior scutellar bristle, with Scer\GAL4^sca-C253

(de Celis et al., 1999)

wing vein L2, with Scer\GAL4^Bx-MS1096

(Lunde et al., 1998)

wing vein L2, with Scer\GAL4^C-765

(de Celis and Barrio, 2000)

wing vein L5, with Scer\GAL4^Bx-MS1096

(Lunde et al., 1998)

wing vein L5, with Scer\GAL4^C-765

(de Celis and Barrio, 2000)

Detailed Description

Statement

Reference

Expression of salr^Scer\UAS.cBa throughout the wing blade driven by Scer\GAL4^C-765 eliminates wing vein L2 and L5.

(de Celis and Barrio, 2000)

Low levels of ectopic salr^Scer\UAS.cBa expression in thoracic cells when driven by Scer\GAL4^C-765 cause a weak expansion of the anterior postalar proneural cluster. Several extra macrochaetae are differentiated in ectopic positions. Stronger ectopic expression of salr^Scer\UAS.cBa driven by Scer\GAL4^C-765 causes a larger expansion of the proneural clusters, including a larger expansion of the dorsocentral and notopleural clusters (which now appear fused). There is also the apparent loss of the postalar proneural cluster and the absence or size reduction of some macrochaetae. When expressed under the control of Scer\GAL4^sca-C253 the macrochaetae are effected dramatically. Only anterior postalar bristles form normally; the others disappear or differentiate as extremely small bristles.

(de Celis et al., 1999)

Flies expressing salr^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 generally lack wing veins L2 and L5. Macrochaetae are also frequently missing from the thorax.

(Lunde et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

salr^Scer\UAS.cBa

salr^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Barrio

(de Celis et al., 1996)

Secondary FlyBase IDs

References (7)

Report Sections

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