FB2026_02 , released June 18, 2026
Allele: Dmel\prdGS
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General Information
Symbol
Dmel\prdGS
Species
D. melanogaster
Name
FlyBase ID
FBal0051258
Feature type
allele
Associated gene
Dmel\prd
Associated Insertion(s)
Carried in Construct
P{prdGS}
Key Links
Transgenic product class
missense_variant
(Bertuccioli et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bertuccioli et al., 1996)
Mutagen
in vitro construct
(Bertuccioli et al., 1996)
Progenitor genotype
prdwt
(Bertuccioli et al., 1996)
Carried in construct
P{prdGS}
Cytology
Description

Protein has a functional prd domain (PD) and a non-functional homeodomain.

(Sheng et al., 1997)

G to S amino acid substitution in the β turn at residue 15 of the paired domain domain. This mutation has been shown to abolish DNA binding in vitro (FBrf0054064).

(Bertuccioli et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
prd
Encoded product / tool
prd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cannot provide prd function in an adult rescue assay. Shows no transcomplementation with prdNQ. Can antagonize endogenous prd function, causing a dominant, partially penetrant, prd phenocopy in embryos.

      (Bertuccioli et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "Prd-GS", expressed in Schneider cells and tested for the proteins ability to transactivate through either the prd domain (PD) binding sites or the NP6 monomeric homeodomain binding sites by assaying Ecol\CAT activity levels.

      (Sheng et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      prdGS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)