FB2026_02 , released June 18, 2026
Allele: Dmel\Src42AYF.hs.sev
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General Information
Symbol
Dmel\Src42AYF.hs.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0051899
Feature type
allele
Associated gene
Dmel\Src42A
Associated Insertion(s)
Carried in Construct
P{sE-Dsrc41YF}
Key Links
Transgenic product class
missense_variant
(Takahashi et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Takahashi et al., 1996)
Mutagen
in vitro construct
(Takahashi et al., 1996)
Progenitor genotype
Carried in construct
P{sE-Dsrc41YF}
Cytology
Description

An Hsp70 promoter and one copy of the 670bp sev enhancer drive expression of a constitutively active form of Src42A (carries the Y511F amino acid replacement).

(Takahashi et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
sev
Encoded product / tool
Src42A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos are lethal due to failure of CNS shortening and dorsal closure. Heterozygous flies exhibit rough eyes associated with extra R7-type neurons.

      (Takahashi et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Constitutively active form of Src42A.

      (Takahashi et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Src41YF.hs.sev
      Src42AYF.hs.sev
      Name Synonyms
      Secondary FlyBase IDs
        References (2)