FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fur1
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General Information
Symbol
Dmel\fur1
Species
D. melanogaster
Name
FlyBase ID
FBal0057365
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion of a P-element.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The pattern of rhabdomeres is disrupted in hemizygous males and homozygous females, with rhabdomeres from neighbouring photoreceptor cells often fusing to form a ring. The fusion is limited to the external rhabdomere membrane in hemizygous males, and the degree of fusion within each ommatidium varies from no fusion, through to fusion of all the rhabdomeres into a ring. All degrees of the fusion phenotype are visible at eclosion. The ommatidia of homozygous females all show the extreme fusion phenotype. The rhabdomeres do not extend the length of the retina, in contrast to wild-type, but are restricted to the distal region. This shortening of the rhabdomeres is distributed evenly across the retina. A decrease in the density of axonal projections is seen both between the retina and the lamina and between the lamina and the medulla. The optic lobe appears less densely organised than normal. The penetrance of a deep mutant pseudopupil phenotype is cold sensitive; at 17oC the penetrance is 92%, at 29oC it is 65%. fur1 mutant photoreceptors have reduced sensitivity to light of all wavelengths compared to wild-type, and lack a prolonged depolarising afterpotential. The eyes of 40 and 60 hour pupae appear normal.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

fur1 shows a high frequency of reversion under dysgenic conditions.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)