FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sh120
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General Information
Symbol
Dmel\Sh120
Species
D. melanogaster
Name
FlyBase ID
FBal0058256
Feature type
allele
Associated gene
Dmel\Sh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  epilepsy
        CEA with eag1
        (Li et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        axon & motor neuron | conditional ts

        (Zhong and Wu, 2004)
        Detailed Description
        Statement
        Reference

        At room temperature, the motor axon terminals of Sh120 larvae show a similar level of arborization to wild-type larvae. However, when larvae are raised at 25oC, the extent of arborization in Sh120 motor terminals is greater than that seen in wild type, although arborization is not further increased when Sh120 larvae are raised at 30oC.

        (Zhong and Wu, 2004)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Statement
        Reference

        Sh120, eag1 has axon & motor neuron phenotype

        (Zhong and Wu, 2004)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        eag1, Sh120; mGluRA112b show the neuromuscular junction overgrowth phenotype of eag1, Sh120 double mutants.

        (Bogdanik et al., 2004)

        The increased arborization of motor axon terminals seen when Sh120 larvae are raised at 25oC is partially suppressed in rut1, Sh120 double mutant larvae.

        eag1, Sh120 double mutant larvae show an enhanced level of motor axon terminal arborization compared to wild-type larvae, when raised at room temperature. No such increase is seen in either single mutant at this temperature. However, when eag1, Sh120 larvae are raised at 30oC, this outgrowth is suppressed as the level of arborization is actually lower than that seen in Sh120 single mutants.

        (Zhong and Wu, 2004)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Sh120
        (Berke et al., 2019, Kasuya et al., 2019, Bogdanik et al., 2004, Zhong and Wu, 2004)
        shaker120
        (Li et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (9)