FB2026_03 , released September 17, 2026
Allele: Dmel\PTKP.a.hs
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General Information
Symbol
Dmel\P\TKP.a.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0058437
Feature type
allele
Associated gene
P\T
Associated Insertion(s)
Carried in Construct
P{A-KP}
Key Links
Transgenic product class
antisense
(Simmons et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
antisense
(Simmons et al., 1996)
Mutagen
in vitro construct
(Simmons et al., 1996)
Progenitor genotype
Carried in construct
P{A-KP}
Cytology
Description

Fragment carrying the KP P-element (deletion of nucleotides 809 to 2563, compared to a full length P-element) cloned from the Sexi strain is fused to an Hsp70 promoter in antisense orientation.

(Simmons et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
P\T
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The presence of Δ2-3 somatic transposase to Muller5-B X chromosome carrying five target P-elements causes pupal lethality, without heat shock P{A-KP} can repress some of the lethality but heat induced expression significantly enhances repression. Combination of P{S-KP} and P{A-KP} can repress pupal lethality, repression is induced or enhanced by heat shock. Combination of P{A-KP} and P{A-NP2}, can repress pupal lethality when induced by heat shock about as effectively as the single construct. P{A-KP} fails to repress gonadal dysgenesis, either through a maternal effect or through a combination of zygotic and maternal effects, with or without heat shock. P{A-KP} cannot repress snw mutability in the male germline or the somatic instability of snw (males have patches of weak sn, extreme sn and wild-type bristles) with or without heat shock. P{A-KP} has no effect on the expression of the Ecol\lacZ gene of P{lacZ}snunspecified or P{lacZ}vasunspecified.

      (Simmons et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      P\TKP.a.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)