FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrx-IV4865
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General Information
Symbol
Dmel\Nrx-IV4865
Species
D. melanogaster
Name
FlyBase ID
FBal0058465
Feature type
allele
Associated gene
Dmel\Nrx-IV
Associated Insertion(s)
Carried in Construct
Also Known As
nrx4865
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Baumgartner et al., 1996)
Mutagen
ethyl methanesulfonate
(Baumgartner et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      embryonic ganglionic branch & embryonic tracheole (with Nrx-IV4025)

      (Paul et al., 2003)

      tracheal dorsal trunk primordium (with Nrx-IV4025)

      (Paul et al., 2003)
      Detailed Description
      Statement
      Reference

      In Nrx-IV4865/Nrx-IV4025 embryos, tracheal phenotypes are apparent from stage 15. At stage 16 in these embryos the average dorsal trunk length is significantly greater than wild type (P<0.005) (116+/-4% mean+/-s.e.m., n>5, normalized to stage 16 wild-type value). In addition these embryos have moderately severe diameter increases in the dorsal trunk and other primary tracheal branches, and some ganglionic branches exhibit missing lumen. Diameter increases are also seen in the primary tracheal branches of Nrx-IV4865 homozygous embryos.

      (Paul et al., 2003)

      Transheterozygotes with Df(3L)vin8 or Df(3L)BK9 are lethal, rare adults escapers are occasionally obtained.

      (Baumgartner et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Trachea in Nrx-IV4865 sinunwu7 double mutants have the same phenotypes as either single mutant.

      (Wu et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nrx-IV4865
      Nrx4865
      (Paul et al., 2003, Baumgartner et al., 1996)
      nrx4865
      (Wu et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)