FB2026_02 , released June 18, 2026
Allele: Hvir\βtβTub85D.PR
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General Information
Symbol
Hvir\βtβTub85D.PR
Species
H. virescens
Name
β-Tubulin at 85D promoter construct of Raff
FlyBase ID
FBal0058642
Feature type
allele
Associated gene
Hvir\βt
Associated Insertion(s)
Carried in Construct
P{β2t-Hvβt}
Transgenic product class
cDNA
(Raff et al., 1997)
wild_type
(Raff et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Raff et al., 1997)
wild_type
(Raff et al., 1997)
Mutagen
in vitro construct
(Raff et al., 1997)
Progenitor genotype
Carried in construct
P{β2t-Hvβt}
Cytology
Description

Expression of a Hvir\βt cDNA encoding the entire coding sequence is under the control of 2.1kb 5' βTub85D regulatory sequences and 1.5kb of 3' βTub85D genomic sequences.

(Raff et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
βTub85D
Encoded product / tool
Hvir\βt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hvir\βt fails to support any microtubule assembly in βTub85D null mutants. When coexpressed with βTub85D, Hvir\βt poisoned all microtubule-mediated processes; spermatid nuclei are not shaped, spermatids are not aligned, spermatid elongation is defective, reflecting failure of axoneme assembly and mitochondrial derivative elongation.

      (Raff et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Drives expression in the postmitotic male germ cells with correct developmental specificity. When Hvir\βt composes more than 6% of the total β-tubulin pool males are sterile.

      (Raff et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hvir\βtβTub85D.PR
      Name Synonyms
      β-Tubulin at 85D promoter construct of Raff
      (Raff et al., 1997)
      Secondary FlyBase IDs
        References (1)