FB2026_02 , released June 18, 2026
Allele: Dmau\marinerTT42I
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General Information
Symbol
Dmau\mariner\TT42I
Species
D. mauritiana
Name
FlyBase ID
FBal0059092
Feature type
allele
Associated gene
Dmau\mariner\T
Associated Insertion(s)
Carried in Construct
P{T42I}
Transgenic product class
missense_variant
(Lohe et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lohe et al., 1996)
Mutagen
ethyl methanesulfonate
(Lohe and Hartl, 1996, Lohe et al., 1996)
Progenitor genotype
Carried in construct
P{T42I}
Cytology
Description

An Hsp70 promoter drives expression of the Dmau\mariner\T coding region containing a T42I amino acid substitution.

(Lohe et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Dmau\mariner\T
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heteroallelic combination with Dmau\mariner\Ths.PL causes a lower excision rate than with Dmau\mariner\Ths.PL alone, regulation by dominant negative complementation (DNC).

      (Lohe and Hartl, 1996)

      P{T42I} mutant Dmau\mariner\T reduces the amount of w::Dmau\wpch.tGa mosaicism. In the absence of heat shock P{T42I} exhibits negative complementation when heterozygous with P{hsp70:Mos1} with respect to the extent of Dmau\mariner element excision from w::Dmau\wpch.tGa in the germline.

      (Lohe et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Assayed in D.melanogaster.

      (Lohe et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dmau\mariner\TT42I
      EMS-73
      (Lohe and Hartl, 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)