FB2026_02 , released June 18, 2026
Allele: Dmel\ninaEN86I
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General Information
Symbol
Dmel\ninaEN86I
Species
D. melanogaster
Name
FlyBase ID
FBal0059987
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
P{Rh1.N86I}
Key Links
Transgenic product class
missense_variant
(Bentrop et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bentrop et al., 1997)
Mutagen
in vitro construct
(Bentrop et al., 1997)
Progenitor genotype
Carried in construct
P{Rh1.N86I}
Cytology
Description

Construct: Amino acid replacement: N86I. 5.5kb KpnI fragment of ninaE.

(Bentrop et al., 1997)
Allele components
Component
Use(s)
Encoded product / tool
ninaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies homozygous for ninaEN86I in a ninaE17 background have a significantly larger electroretinogram (ERG) amplitude than that of ninaE17 flies. The prolonged depolarizing afterpotential is absent in flies homozygous for ninaEN86I in a ninaE17 background, but otherwise the ERG responses are similar to wild-type in both amplitude and waveform, and the on- and off-transients are present. Rhabdomeres appear largely normal in flies homozygous for ninaEN86I in a ninaE17 background at eclosion, but by 4 weeks after eclosion, most R1-R6 rhabdomeres are absent. All R1-R6 rhabdomeres are missing by 6 weeks after eclosion. This phenotype is completely recessive.

      (Bentrop et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Flies homozygous for ninaEN86I in a ninaE17 background have less than 2% of the wild-type amount of rhodopsin.

      (Bentrop et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      N86I
      (Bentrop, 1998)
      ninaEN86I
      Name Synonyms
      Secondary FlyBase IDs
        References (2)