FB2026_02 , released June 18, 2026
Allele: Dmel\ninaEL81Q
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General Information
Symbol
Dmel\ninaEL81Q
Species
D. melanogaster
Name
FlyBase ID
FBal0059988
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
P{Rh1.L81Q}
Key Links
Transgenic product class
missense_variant
(Bentrop et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bentrop et al., 1997)
Mutagen
in vitro construct
(Bentrop et al., 1997)
Progenitor genotype
Carried in construct
P{Rh1.L81Q}
Cytology
Description

Construct: Amino acid replacement: L81Q. 5.5kb KpnI fragment of ninaE.

(Bentrop et al., 1997)
Allele components
Component
Use(s)
Encoded product / tool
ninaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies homozygous for ninaEL81Q in a ninaE17 background have a significantly larger electroretinogram (ERG) amplitude than that of ninaE17 flies. The prolonged depolarizing afterpotential is absent in flies homozygous for ninaEL81Q in a ninaE17 background, but otherwise the ERG responses are similar to wild-type in both amplitude and waveform, and the on- and off-transients are present. Flies homozygous for ninaEL81Q in a ninaE17 background have intact rhabdomeres and normal subrhabdomeral catacombs at eclosion. Microvilli remain largely intact until approximately 4 weeks after eclosion, when the catacomb-like structures deteriorate and the rhabdomere membrane begins to fill the rhabdomeric stalk as vesicles or sheets of apposed membranes. Approximately half the R1-R6 rhabdomres have degenerated by 8 weeks after eclosion, and signs of membrane shedding into the extracellular cavity are visible. This phenotype is completely recessive.

      (Bentrop et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Flies homozygous for ninaEL81Q in a ninaE17 background have approximately 20% of the wild-type amount of rhodopsin.

      (Bentrop et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      L81Q
      (Bentrop, 1998)
      ninaEL81Q
      Name Synonyms
      Secondary FlyBase IDs
        References (2)