FlyBase Allele Report: Dmel\bic[vr22P3]

General Information

Symbol

Dmel\bic^vr22P3

Species

D. melanogaster

Name

FlyBase ID

FBal0060491

Feature type

allele

Associated gene

Dmel\bic

Associated Insertion(s)

P{}bic^vr22P3

Carried in Construct

Also Known As

49Da¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Lasko and Pardue, 1988)

P-element activity

(Markesich and Beckingham, 1997)

Progenitor genotype

Associated Insertion(s)

P{}bic^vr22P3

Cytology

Description

P-element insertion in the 5' UTR, 46 residues upstream of the small intron.

(Markesich et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:12,870,276..12,870,283 [+]

(Markesich et al., 2000, Markesich and Beckingham, 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Markesich et al., 2000, Markesich and Beckingham, 1997)

some die during embryonic stage | recessive

(Markesich et al., 2000, Markesich and Beckingham, 1997)

Phenotype Manifest In

embryo | anterior

(Markesich et al., 2000)

Detailed Description

Statement

Reference

Homozygotes die as embryos, mostly during late embryogenesis with variable defects which are mainly in the anterior of the embryo. Bicaudal embryos are never seen.

(Markesich et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bic^vr22P3 is rescued by bic^+tC42

(Markesich et al., 2000)

bic^vr22P3 is rescued by bic^+tcosG1.8

(Markesich et al., 2000)

bic^vr22P3 is rescued by bic^+tNco4

(Markesich et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lasko.

Comments

Excision of the P-element indicates that the P-element insertion in bic^vr22P3 causes the mutant phenotype.

(Markesich et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

49Da¹

(Markesich et al., 2000, Lasko and Pardue, 1988)

E(Bic)

(Markesich et al., 2000)

E(Bic)^49Da-1

bic^vr22P3

l(2)49Da¹

l(2)P3

vr22^P3

(Markesich and Beckingham, 1998, Markesich and Beckingham, 1996, Wu and Howe, 1995)

vr22P3

(Gajewski et al., 1990)

Name Synonyms

Secondary FlyBase IDs

FBal0003300

References (7)

Report Sections

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