FlyBase Allele Report: Dmel\CycB[UAS.cRa]

General Information

Symbol

Dmel\CycB^UAS.cRa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Rimmington

FlyBase ID

FBal0062017

Feature type

allele

Associated gene

Dmel\CycB

Associated Insertion(s)

Carried in Construct

P{UAS-CycB.R}

Key Links

Transgenic product class

inframe_deletion

(Rimmington et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Rimmington et al., 1994)

Mutagen

in vitro construct

(Rimmington et al., 1994)

Progenitor genotype

Carried in construct

P{UAS-CycB.R}

Cytology

Description

CycB sequences encoding an N-terminally deleted protein lacking the first 140 amino acids are expressed under the control of UASt regulatory sequences.

(Rimmington et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

CycB

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | adult stage, with Scer\GAL4^69B

(Rimmington et al., 1994)

decreased body size | adult stage, with Scer\GAL4^69B

(Rimmington et al., 1994)

lethal - all die before end of pupal stage, with Scer\GAL4^69B

(Rimmington et al., 1994)

some die during pupal stage, with Scer\GAL4^69B

(Rimmington et al., 1994)

Phenotype Manifest In

eye, with Scer\GAL4^69B

(Rimmington et al., 1994)

macrochaeta, with Scer\GAL4^69B

(Rimmington et al., 1994)

wing, with Scer\GAL4^69B

(Rimmington et al., 1994)

Detailed Description

Statement

Reference

The majority of flies expressing CycB^Scer\UAS.cRa under the control of Scer\GAL4^69B survive only to late pupal stages, with less than 0.1% surviving to adulthood. These adults are smaller than normal and have a number of defects, including rough eyes, deformed wings and abnormal bristles. The mitotic index of third instar larval brains appears normal overall, although there are a very high proportion of anaphase stages, which sometimes show abnormal separation of condensed chromatin masses.

(Rimmington et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CycB^Scer\UAS.cRa

CycB^UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Rimmington

(Rimmington et al., 1994)

Secondary FlyBase IDs

References (1)

Report Sections

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