FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Antp1.D,4.E.A.hs
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General Information
Symbol
Dmel\Antp1.D,4.E.A.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0062173
Feature type
allele
Associated gene
Dmel\Antp
Associated Insertion(s)
Carried in Construct
P{HS-Antp[1.D,4.E]A}
Key Links
Transgenic product class
missense_variant
(Jaffe et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Jaffe et al., 1997)
Mutagen
in vitro construct
(Jaffe et al., 1997)
Progenitor genotype
Antphs.PJ
(Jaffe et al., 1997)
Carried in construct
P{HS-Antp[1.D,4.E]A}
Cytology
Description

Construct: Amino acid replacement: D38A. Amino acid replacement: E367A.

(Jaffe et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Antp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos exhibit the class IV phenotype. Expression of two copies causes transformation of T1 to a T2 identity with complete loss of the T1 beard, head segments are also transformed to a T2 identity (all normal head structures are missing and two or three T2-like denticle belts are seen on the head). Embryos also exhibit an absence of Keilin's organs, shortened denticle belts and a failure of germ band retraction.

      (Jaffe et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phosphorylation at sites 1 and 4 by Ck2, or by a kinase with very similar substrate specificity, is important for modulating Antp activity in vivo.

      (Jaffe et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Antp1.D,4.E.A.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)