FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp70Bc+t14
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General Information
Symbol
Dmel\Hsp70Bc+t14
Species
D. melanogaster
Name
FlyBase ID
FBal0063183
Feature type
allele
Associated gene
Dmel\Hsp70Bc
Associated Insertion(s)
Carried in Construct
P{FRT(whs,3Xwt70).A}
Key Links
Genomic Maps

Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Krebs and Feder, 1998, Krebs et al., 1998, Welte et al., 1993)
Progenitor genotype
Carried in construct
P{FRT(whs,3Xwt70).A}
Cytology
Description

14kb HindIII fragment of plasmid G3 carrying three Hsp70 genes is cloned between two direct FRT sites.

(Welte et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70Bc
Encoded product / tool
Hsp70Bc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:12,499,701..12,513,570 [+]
Linked to:
HindIII-HindIII restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Welte et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Hsp70Bb+t14 and Hsp70Bc+t14 after heat shock (in animals carrying P{FRT(whs,3Xwt70).A}) does not confer enhanced protection against hyperthermia, but has deleterious effects on parameters of larval locomotory behaviour.

      (Klose et al., 2005)

      A 30 minute exposure at 36oC in females carrying extra copies of Hsp70 (female carrying P{>whs,3Xwt70>A}) results in a decrease in the proportion of eggs that hatch compared to control heat shocked flies. A 60 minute exposure to 36oC results in a decrease in the proportion of eggs that hatch both in control heat shocked flies and in flies carrying extra copies of Hsp70 (female carrying P{>whs,3Xwt70>A}).

      (Silbermann and Tatar, 2000)

      First instar larvae carrying P{>whs,3Xwt70>A} are more thermotolerant than control larvae in the absence of pretreatment or with a 10 minute pretreatment at 36oC before heat shock. Control larvae are more thermotolerant than larvae carrying P{>whs,3Xwt70>A} if they receive a 30 minute pretreatment before heat shock.

      (Krebs and Feder, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Hsp70Bc+t14;Hsp70Bb+t14 double mutant adults do not show any eye defects.

      (Huen and Chan, 2005)

      Flies carrying P{>whs,3Xwt70>A} are more resistant to paraquat than control lines. Flies carrying P{>whs,3Xwt70>A} and subjected to heat shock do not show enhanced stress resistance compared to control lines subjected to heat shock.

      (Minois, 2001)
      Xenogenetic Interactions
      Statement
      Reference

      The progressive degeneration and pigmentation loss eye phenotype characteristic for flies expressing Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU is not modified by combination with Hsp70Bc+t14 together with Hsp70Bb+t14.

      (Huen and Chan, 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsp70Bc+t14
      Name Synonyms
      Secondary FlyBase IDs
        References (13)