FlyBase Allele Report: Dmel\tws[v158]

General Information

Symbol

Dmel\tws^v158

Species

D. melanogaster

Name

FlyBase ID

FBal0063711

Feature type

allele

Associated gene

Dmel\tws

Associated Insertion(s)

P{lArB}tws^v158

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Omelyanchuk and Lebedeva, 1997)

Progenitor genotype

Associated Insertion(s)

P{lArB}tws^v158

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Chubykin and Omelyanchuk, 1997, Chubykin et al., 1997)

abnormal mitotic cell cycle

(Lebedeva et al., 2003, Chubykin et al., 1997, Omel'yanchuk et al., 1997, Omelyanchuk and Lebedeva, 1997)

partially lethal - majority die

(Chubykin et al., 1997)

Phenotype Manifest In

chromosome, centromeric region

(Lebedeva et al., 2000)

ganglion | larval stage

(Chubykin and Omelyanchuk, 1997)

germarium

(Chubykin and Omelyanchuk, 1997)

larval brain & nuclear chromosome

(Omelyanchuk and Lebedeva, 1997)

mitotic anaphase

(Lebedeva et al., 2003)

mitotic cell cycle

(Lebedeva et al., 2003, Lebedeva et al., 2000)

ovary

(Chubykin and Omelyanchuk, 1997)

testis

(Chubykin and Omelyanchuk, 1997)

Detailed Description

Statement

Reference

Cells of the neural ganglia of mutant larvae show defects in chromosome segregation during mitosis; monopolar anaphases, separation of chromatids to an abnormally short distance in anaphase and bridging or lagging of some chromatids or prolonged asynchronous separation of sister chromatid sets to the poles in anaphase are seen.

(Lebedeva et al., 2003)

Centromere disjunction is affected in mutant flies. This results in arrest of either mitosis or anaphase initiation in imaginal discs, whereas in the neural ganglions, chromosomes integrate into a monopolar spindle at prophase and unipolar cells appear in anaphase.

(Lebedeva et al., 2000)

Shows additional apoptosos in the germarium and early ovarian chambers, the proximal part of the adult testis and larval neural ganglions.

(Chubykin and Omelyanchuk, 1997)

Abnormal mitotic chromosome condensation and appearance of chromosome-like bodies: damaging of chromocenter reorganisation in mitotic cells. Meiotic cell development is also abnormal: defects in male and female meiosis.

(Chubykin et al., 1997)

Anomalous mitoses in homozygous larvae.

(Omel'yanchuk et al., 1997)

Abnormal mitotic activity as assayed in the larval brain.

(Omelyanchuk and Lebedeva, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

aar(V158)

(Lebedeva et al., 2003)

tws^v158

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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