FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Src64BKR.hs.2sev
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General Information
Symbol
Dmel\Src64BKR.hs.2sev
Species
D. melanogaster
Name
FlyBase ID
FBal0065000
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Construct: Two copies of the sev enhancer linked to an Hsp70 promoter drive expression of a catalytically inactive form of Src64B with the amino acid replacement: K312R at the putative ATP-binding site.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of Src64BKR.hs.2sev by heat shock at 37oC for 1 hour every other day during development results in reduced viability. Approximately 65% of embryos carrying two copies of Src64BKR.hs.2sev show abnormalities in the central nervous system when Src64BKR.hs.2sev is expressed using a 30 minute heat shock at 37oC between 5 and 8 hours of development. Gaps between some segments are seen within the longitudinal connectives, and there is fusion of the anterior and posterior commissures within some segments. Expression of Src64BKR.hs.2sev causes mild roughening of the eye. A small number of ommatidia have less than seven rhabdomeres.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Src64BKR.hs.2sev
Name Synonyms
Secondary FlyBase IDs
    References (1)