FB2026_03 , released September 17, 2026
Allele: Dmel\rdgB::RnorPitpnaninaE.PM
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General Information
Symbol
Dmel\rdgB::Rnor\PitpnaninaE.PM
Species
D. melanogaster
Name
neither inactivation nor afterpotential E promoter construct of Milligan
FlyBase ID
FBal0082304
Feature type
allele
Associated gene
rdgB::Rnor\Pitpna
Associated Insertion(s)
Carried in Construct
P{pitpĪ±-rdgB}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Milligan et al., 1997)
Progenitor genotype
Carried in construct
P{pitpĪ±-rdgB}
Cytology
Description

A chimeric construct consisting of full length rdgB in which the PITP domain has been replaced by Rnor\Pitpna is expressed under the control of a ninaE promoter.

(Milligan et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
rdgB::Rnor\Pitpna
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing rdgB::Rnor\PITPNAninaE.PM in a wild-type background have a dose-dependent loss of the deep pseudopupil. The flies have numerous holes in the retina and the R1-R6 rhabdomeres are reduced in size relative to the R7 rhabdomere. The R1-R6 microvillar rhabdomeres show some signs of unpacking. The ERG light response amplitude of flies expressing rdgB::Rnor\PITPNAninaE.PM in a wild-type background is essentially wild-type.

      (Milligan et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fails to rescue rdgB2, and may cause additional adverse effects; the initial electroretinogram (ERG) light response of rdgB2 flies carrying rdgB::Rnor\PITPNAninaE.PM has a significantly smaller amplitude than that of rdgB2 flies.

      (Milligan et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      rdgB::Rat\PITPNAninaE.PM
      rdgB::Rnor\PITPNAninaE.PM
      rdgB::Rnor\PitpnaninaE.PM
      Name Synonyms
      neither inactivation nor afterpotential E promoter construct of Milligan
      (Milligan et al., 1997)
      Secondary FlyBase IDs
        References (1)