FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\paraDN7
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General Information
Symbol
Dmel\paraDN7
Species
D. melanogaster
Name
FlyBase ID
FBal0082379
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pittendrigh et al., 1997)
Progenitor genotype
Cytology
Description

Mutation within the intracellular S4-S5 linker, in domain III.

(ffrench-Constant et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,475,737..16,475,737 [-]
Nucleotide change:

C16475737T

Amino acid change:

A1422V | para-PA; A1375V | para-PAA; A1377V | para-PAB; A1375V | para-PAC; A1377V | para-PAD; A1399V | para-PAE; A1401V | para-PAF; A1380V | para-PAG; A1398V | para-PAH; A1377V | para-PAI; A1423V | para-PAJ; A1388V | para-PAK; A1402V | para-PAL; A1374V | para-PAM; A1434V | para-PAN; A1404V | para-PAO; A1388V | para-PAP; A1380V | para-PAQ; A1358V | para-PAS; A1347V | para-PAT; A1353V | para-PAW; A1390V | para-PAX; A1423V | para-PAY; A1402V | para-PAZ; A1422V | para-PB; A1423V | para-PBA; A1357V | para-PBB; A1347V | para-PBD; A1422V | para-PBF; A1422V | para-PBG; A1346V | para-PBH; A1422V | para-PC; A1405V | para-PD; A1399V | para-PE; A1399V | para-PF; A1378V | para-PG; A1388V | para-PH; A1370V | para-PI; A1391V | para-PJ; A1367V | para-PK; A1378V | para-PL; A1391V | para-PM; A1391V | para-PN; A1383V | para-PO; A1412V | para-PP; A1367V | para-PQ; A1370V | para-PR; A1391V | para-PS; A1401V | para-PT; A1409V | para-PU; A1388V | para-PV; A1393V | para-PW; A1416V | para-PX; A1429V | para-PY; A1380V | para-PZ

Comment:

The nature of the nucleotide substitution in the mutant was inferred by a FlyBase curator based on the reported amino acid change. The location of the amino acid change was reported in the context of the surrounding amino acid sequence.

(Pittendrigh et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      para74 and para74/paraDN7 flies show increased resistance to allethrin compared to wild type lifes in a lethality assay.

      (Martin et al., 2000)

      Homozygous flies show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies. Homozygous flies have a modest level of resistance (9.76 fold) to deltamethrin compared to wild-type flies. para74/paraDN7 transheterozygotes have a 105 fold resistance to deltamethrin compared to wild-type flies. This high level of resistance is not altered if the flies also carry Tp(1;2)r+75c.

      (Pittendrigh et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      paraDN7
      Name Synonyms
      Secondary FlyBase IDs
        References (3)