FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SerS.UAS.Tag:MYC
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General Information
Symbol
Dmel\SerS.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0083243
Feature type
allele
Associated gene
Dmel\Ser
Associated Insertion(s)
Carried in Construct
P{UAS-Ser.S}
Also Known As
UAS-DN-Ser
Key Links
Transgenic product class
stop_gained
(Sun and Artavanis-Tsakonas, 1997)
Mutagen
Nature of the Allele
Transgenic product class
stop_gained
(Sun and Artavanis-Tsakonas, 1997)
Mutagen
in vitro construct
(Sun and Artavanis-Tsakonas, 1997)
Progenitor genotype
Carried in construct
P{UAS-Ser.S}
Cytology
Description

A stop codon has been inserted just C-terminal to the last EGF-like repeat, approximately 250 amino acids upstream of the transmembrane domain. Three copies of Tag:MYC have been added to the carboxy-terminus, and expression is governed by UAS regulatory sequences.

(Sun and Artavanis-Tsakonas, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ser
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of SerS.Scer\UAS.T:Hsap\MYC with Scer\GAL4Ubx-lac1-Gal4 does not affect wing patterning.

      (Pallavi and Shashidhara, 2003)

      When expression is driven by Scer\GAL4c311 flies have reduced eyes with highly irregular ommatidial patterning.

      (Gibson and Schubiger, 2000)

      When expressed via Scer\GAL4hs.2sev the eyes are roughened. Phenotype is stronger than for SerS.GMR.T:Hsap\MYC, with extra photoreceptor defects. When expressed via Scer\GAL4T113 a small eye phenotype results. Each ommatidium is square rather than hexagonal, although photoreceptor composition and orientation are normal. When expressed via Scer\GAL4vg.int2.1 wings may be missing the anterior margin or be narrow. The phenotype of SerS.Scer\UAS.T:Hsap\MYC is more extreme than that of DlS.Scer\UAS.T:Hsap\MYC under these circumstances. This phenotype can be suppressed by simultaneous expression of SerScer\UAS.cSa. When expressed via Scer\GAL4A9 no extra wing vein is observed, although extensive scalloping of the wing margin occurs.

      (Sun and Artavanis-Tsakonas, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SerS.Scer\UAS.T:Hsap\MYC
      SerS.UAS.T:Myc
      SerS.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)