FB2026_02 , released June 18, 2026
Allele: Dmel\RpS3Aa.hs
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General Information
Symbol
Dmel\RpS3Aa.hs
Species
D. melanogaster
Name
antisense heat shock construct
FlyBase ID
FBal0083250
Feature type
allele
Associated gene
Dmel\RpS3A
Associated Insertion(s)
Carried in Construct
P{hs-RpS3A.a}
Key Links
Transgenic product class
antisense
(Reynaud et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
antisense
(Reynaud et al., 1997)
Mutagen
in vitro construct
(Reynaud et al., 1997)
Progenitor genotype
Carried in construct
P{hs-RpS3A.a}
Cytology
Description

Full length RpS3A cDNA is expressed in the antisense orientation under the control of an Hsp70 promoter.

(Reynaud et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
RpS3A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Repeated heat shocks of animals carrying RpS3Aa.hs prolongs larval and pupal development and produces small adults. This defect is also seen if the animals are raised at 25oC without heat shock. Females carrying RpS3Aa.hs show a significant reduction in the number of eggs laid even at 25oC, and after heat shock treatment egg production is dramatically reduced so that no eggs are laid after 3 days. Vitellogenic egg chambers of heat shocked females have a variety of abnormalities, including disruption of the follicular epithelium, mislocalised or pyknotic nuclei and fused nurse cells.

      (Reynaud et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RpS3Aa.hs
      Name Synonyms
      antisense heat shock construct
      (Reynaud et al., 1997)
      Secondary FlyBase IDs
        References (1)