FB2026_02 , released June 18, 2026
Allele: Dmel\EcRF288Y
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General Information
Symbol
Dmel\EcRF288Y
Species
D. melanogaster
Name
FlyBase ID
FBal0083492
Feature type
allele
Associated gene
Dmel\EcR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bender et al., 1997)
Progenitor genotype
Cytology
Description

Mutation is in the DNA-binding domain (numbering with respect to the EcR-B1 open reading frame).

(Bender et al., 1997)

Nucleotide substitution: T?A.

(Bender et al., 1997)

Amino acid replacement: F288Y.

(Bender et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:6,094,888..6,094,888 [-]
Nucleotide change:

T6094888A

Reported nucleotide change:

T?A

Amino acid change:

F259Y | EcR-PA; F288Y | EcR-PB; F79Y | EcR-PC; F259Y | EcR-PD; F259Y | EcR-PE; F288Y | EcR-PG

Reported amino acid change:

F288Y

(Bender et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      EcRF288Y/+ flies have reduced amounts of daytime sleep compared to controls. The reduction is greater in females compared to males. Nighttime sleep is increased in both male and female EcRF288Y/+ flies.

      (Ishimoto and Kitamoto, 2010)

      Trained heterozygous EcRF288Y mutant males display normal courtship short-term memory in behavioural assays, but are defective in long-term memory. Defects in long-term memory are rescued by feeding heterozygous males the steroid hormone 20-hydroxyecdysone (20E) during the training period.

      (Ishimoto et al., 2009)

      EcRF288Y heterozygous adults exhibit a significant increase in lifespan as compared o controls.

      (Simon et al., 2003)

      Some EcRF288Y/EcRM554fs animals pupariate, but they do not survive to adulthood.

      (Bender et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      EcRF288Y
      (Ishimoto and Kitamoto, 2010, Ishimoto et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)