FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Med14
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General Information
Symbol
Dmel\Med14
Species
D. melanogaster
Name
FlyBase ID
FBal0090596
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hudson et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: W483term.

(Hudson et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,613,935..31,613,935 [+]
Nucleotide change:

G31613935A

Amino acid change:

W509term | Med-PA; W435term | Med-PB; W509term | Med-PC

Reported amino acid change:

W483term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Hudson et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal in trans with Med12, Med13, Med11, Med16, Med18 or Df(3R)E40. Females containing homozygous Med13 germ line clones mated to Med14/+ males produce eggs of two phenotypic classes: 48% have a partially ventralised phenotype (presumptive zygotic genotype Med13/+). The second class of embryos (presumptive zygotic genotype Med13/Med14) do not differentiate any dorsal structures, but instead differentiate ventral denticle bands around the entire embryonic circumference. These embryos do not differentiate amnioserosa.

      (Hudson et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Med14, zen1 has lethal | recessive | embryonic stage phenotype

      (Hudson et al., 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Med14/Med[+] is an enhancer of phenotype of dpphr4

      (Hudson et al., 1998)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Med14
      (Newton et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)