FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pp4-19Ccmm
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General Information
Symbol
Dmel\Pp4-19Ccmm
Species
D. melanogaster
Name
centrosomes minus microtubules
FlyBase ID
FBal0091661
Feature type
allele
Associated gene
Dmel\Pp4-19C
Associated Insertion(s)
P{}Pp4-19Ccmm
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Helps et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{}Pp4-19Ccmm
Cytology
Description

Insertion of a 0.68kb P-element in the 5' untranslated region of Pp4-19C, 818bp 5' of the initiating ATG codon.

(Helps et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 25% of embryos derived from homozygous females mated to wild-type males hatch, and approximately 30% of embryos derived from homozygous females mated to hemizygous males hatch, indicating that this is a maternal effect mutation. Nuclei in different regions of homozygous embryos are seen in different stages of mitosis during the first 14 mitotic cycles, in contrast to wild-type embryos. Regions containing free centrosomes that are not associated with polar microtubules or DNA are seen. In addition, nuclei in mitotic arrest and aberrant polar microtubule structures are seen.

      (Helps et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P-element reverts the semi-lethal phenotype.

      (Helps et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pp4-19Ccmm
      cmm
      (Cohen et al., 2005, Helps et al., 1998)
      Name Synonyms
      centrosomes minus microtubules
      (Helps et al., 1998)
      Secondary FlyBase IDs
        References (2)