FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tkv2ΔGSK.UAS
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General Information
Symbol
Dmel\tkv2ΔGSK.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0092482
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{UAS-tkv.2ΔGSK}
Key Links
Transgenic product class
dominant_negative_variant
(Haerry et al., 1998)
inframe_deletion
(Haerry et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Haerry et al., 1998)
inframe_deletion
(Haerry et al., 1998)
Mutagen
in vitro construct
(Haerry et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-tkv.2ΔGSK}
Cytology
Description

A dominant negative form of the tkv2 isoform, in which the GS box and kinase domain are deleted, is expressed under the control of UAS regulatory sequences.

(Haerry et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing tkv2ΔGSK.Scer\UAS under the control of Scer\GAL4A9 have a similar phenotype to flies expressing tkv1ΔGSK.Scer\UAS or tkv1AΔGS.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4A9.

      (Haerry et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tkv2ΔGSK.Scer\UAS
      tkv2ΔGSK.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)