FlyBase Allele Report: Dmel\pon[P65]

General Information

Symbol

Dmel\pon^P65

Species

D. melanogaster

Name

FlyBase ID

FBal0093808

Feature type

allele

Associated gene

Dmel\pon

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lu et al., 1998)

Progenitor genotype

Cytology

Description

Deletion removing the translation initiation codon.

(Lu et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval pericardial cell

(Lu et al., 1998)

larval somatic muscle cell

(Lu et al., 1998)

muscle cell of abdominal 2 lateral transverse muscle 3

(Lu et al., 1998)

muscle cell of abdominal 3 lateral transverse muscle 3

(Lu et al., 1998)

muscle cell of abdominal 4 lateral transverse muscle 3

(Lu et al., 1998)

muscle cell of abdominal 5 lateral transverse muscle 3

(Lu et al., 1998)

muscle cell of abdominal 6 lateral transverse muscle 3

(Lu et al., 1998)

muscle cell of abdominal 7 lateral transverse muscle 3

(Lu et al., 1998)

Detailed Description

Statement

Reference

The number of eve-positive pericardial cells is reduced in mutant embryos. There is a severe reduction and disorganisation of somatic muscles; LT3 frequently appears to be transformed into LT4.

(Lu et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Df(3R)Exel6157/+, pon^P65 has cardiogenic mesoderm phenotype

(Ahmad et al., 2012)

Df(1)CHES-1-like¹/+, pon^P65 has cardiogenic mesoderm phenotype

(Ahmad et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

pon^P65/+ ; Df(3R)Exel6157/+ double heterozygous embryos show asymmetric cell division defects in "svp" cardiac progenitor cells that are significantly more severe than the additive effects of each of the two single heterozygotes. Defects in the symmetric cell divisions that give rise to the tin-expressing cardial cells in the double heterozygotes are not significantly different from the additive effects of each of the two single heterozygotes.

pon^P65/+ ; Df(1)CHES-1-like¹/+ double heterozygous embryos show asymmetric cell division defects in "svp" cardiac progenitor cells that are significantly more severe than the additive effects of each of the two single heterozygotes. Defects in the symmetric cell divisions that give rise to the tin-expressing cardial cells in the double heterozygotes are not significantly different from the additive effects of each of the two single heterozygotes.

(Ahmad et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pon^P65

(Ahmad et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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