FB2026_02 , released June 18, 2026
Allele: Dmel\lush+tKa
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General Information
Symbol
Dmel\lush+tKa
Species
D. melanogaster
Name
FlyBase ID
FBal0093853
Feature type
allele
Associated gene
Dmel\lush
Associated Insertion(s)
Carried in Construct
P{lush+tKa}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Kim et al., 1998)
wild_type
(Kim et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Kim et al., 1998)
wild_type
(Kim et al., 1998)
Mutagen
in vitro construct
(Kim et al., 1998)
Progenitor genotype
Carried in construct
P{lush+tKa}
Cytology
Description

A 4.8kb genomic DNA fragment uncovering the lush locus.

(Kim et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
lush
Encoded product / tool
lush
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:19,603,105..19,607,341 [-]
Linked to:
START-BamHI restriction fragment
Comment:

Location of 5' end is approximated by curator, according to author statment. Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Kim et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying six copies of lush+tKa have normal olfactory responses to ethanol.

      (Kim et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      lush+tKa rescues lush1

      (Xu et al., 2005)

      lush+tKa rescues lush1

      (Wang et al., 2001)

      lush+tKa rescues lush1

      (Kim et al., 1998)
      Comments

      The presence of lush+tKa rescues lush1 mutant T1 neuron responsiveness to 11-cis vaccenyl acetate.

      lush1 mutant flies transformed with a copy of lush+tKa respond to 11-cis vaccenyl acetate and male flies in behavioural attraction assays.

      Normal spontaneous activity rates are restored to T1 neurons upon introduction of lush+tKa.

      lush1 mutants expressing lush+tKa have inhibitory responses to concentrated alcohol restored.

      (Xu et al., 2005)

      Rescues the abnormal response to benzaldehyde in a T-maze assay seen in lush1 flies.

      (Wang et al., 2001)

      Completely restores wild-type olfactory behaviour to lush1 flies.

      (Kim et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lush+tKa
      lushwt-DS
      (Gomez-Diaz et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)