FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\aptamerhs.Cdk2.pep4
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General Information
Symbol
Zzzz\aptamerhs.Cdk2.pep4
Species
a. artificial
Name
FlyBase ID
FBal0094592
Feature type
allele
Associated gene
Zzzz\aptamer
Associated Insertion(s)
Carried in Construct
P{hs-pep4.Cdk2}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kolonin and Finley, 1998)
Progenitor genotype
Carried in construct
P{hs-pep4.Cdk2}
Cytology
Description

An aptamer peptide (pep4) that binds Cdk2 protein is expressed as a conformationally constrained loop by fusing it to a stable platform molecule (the Escherichia coli trxA protein). It is expressed under the control of an Hsp70 promoter.

(Kolonin and Finley, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Zzzz\aptamer
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Zzzz\aptamerhs.cdc2c.pep4.T:Ecol\trxA using cyclic heat shock from the third larval instar until eclosion often have eye defects. Phenotypes include rough eyes with disorganised ommatidia and bristles. The phenotype is dosage-dependent.

      (Kolonin and Finley, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Zzzz\aptamerhs.Cdk2.pep4 has eye phenotype, suppressible by Cdk2hs.PS

      (Kolonin and Finley, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The phenotype is suppressed by coexpression of cdc2chs.PS but is almost unaffected by coexpression of cdc2hs.PS.

      (Kolonin and Finley, 1998)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Zzzz\aptamerhs.Cdk2.pep4.T:Ecol\trxA
      Zzzz\aptamerhs.Cdk2.pep4
      Zzzz\aptamerhs.cdc2c.pep4.T:Ecol\trxA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)