FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\prosS8
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General Information
Symbol
Dmel\prosS8
Species
D. melanogaster
Name
FlyBase ID
FBal0095240
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mortin, 1990)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Demidenko et al., 2001)

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal30 amino acids of the wild-type product.

(Demidenko et al., 2001)

Amino acid replacement: W1378term.

(Demidenko et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:11,392,006..11,392,006 [+]
Nucleotide change:

G11392006A

Reported nucleotide change:

G?A

Amino acid change:

W1645term | pros-PH; W1806term | pros-PI; W1374term | pros-PJ; W1506term | pros-PK; W1345term | pros-PL; W1674term | pros-PM

Reported amino acid change:

W1378term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Demidenko et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Anterior and posterior commissures fail to separate and longitudinal connectives do not form. Axon pathfinding from the sensory organs in the PNS is abnormal, so the sensilla fail to innervate the CNS.

      (Demidenko et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced with: RpII140S8.

      (Krasnoselskaya et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      S8
      (Mortin, 1990)
      anon-S8S8
      l(3)S8
      (Krasnoselskaya et al., 1998)
      l(3R)S8
      (Demidenko et al., 1999)
      pros S8
      (Demidenko et al., 2001)
      prosS8
      Name Synonyms
      Secondary FlyBase IDs
        References (5)