FB2026_02 , released June 18, 2026
Allele: Dmel\hook8
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General Information
Symbol
Dmel\hook8
Species
D. melanogaster
Name
FlyBase ID
FBal0095356
Feature type
allele
Associated gene
Dmel\hook
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kramer and Phistry, 1999)
Progenitor genotype
Cytology
Description

Nucleotide substitution stated to be C1991T, but 1991 is a typographical error (corrected, see Kramer, 1999.12.2, personal communication). Amino acid replacement: ?244@.

(Kramer and Phistry, 1999)

Nucleotide substitution: C1191T.

(Kramer, 1999.12.2)

Amino acid replacement: ?245term.

(Kramer, 1999.12.2)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,032,593..19,032,593 [-]
Nucleotide change:

C19032593T

Amino acid change:

Q245term | hook-PA

(Kramer and Phistry, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes have a hooked-bristle phenotype.

      (Kramer and Phistry, 1999)

      The number of large mature multivesicular bodies in the ommatidia of hk8 larval eye disks is one-sixth that of wild type. The number of multilammelar late endosomes or lysosomes is increased compared to wild type.

      (Sunio et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      hook1

      (Kramer and Phistry, 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that fails to complement hk1.

      (Kramer and Phistry, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hk8
      hook8
      Name Synonyms
      Secondary FlyBase IDs
        References (3)