FlyBase Allele Report: Dmel\Egfr[2.W15R.L24V.UAS]

General Information

Symbol

Dmel\Egfr^{2.W15R.L24V.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0095738

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{Egfr.2.W15R.L24V.UAS}

Key Links

Transgenic product class

missense_variant

(Lesokhin et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Lesokhin et al., 1999)

Mutagen

in vitro construct

(Lesokhin et al., 1999)

Progenitor genotype

Carried in construct

P{Egfr.2.W15R.L24V.UAS}

Cytology

Description

Expression of mutant Type 2 Egfr coding region (carries the amino acid replacements W15R and L24V) is governed by UASt regulatory sequences.

(Lesokhin et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^h-H10

(Lesokhin et al., 1999)

ommatidium, with Scer\GAL4^h-H10

(Lesokhin et al., 1999)

wing, with Scer\GAL4^32B

(Lesokhin et al., 1999)

wing vein, with Scer\GAL4^32B

(Lesokhin et al., 1999)

Detailed Description

Statement

Reference

When expression is driven by Scer\GAL4^32B there is no effect on wing development. When expression is driven by Scer\GAL4^h-H10 there is no effect on eye development. When expression is driven at higher levels (induced by raised temperature) with Scer\GAL4^32B extra wing vein appears - similar to that caused by expression of Egfr^{2.A887T.Scer\UAS} at lower levels. When expression is driven at higher levels (induced by raised temperature) with Scer\GAL4^h-H10 mutant eye phenotype appears - similar to that caused by expression of Egfr^{2.A887T.Scer\UAS} at lower levels. Most cells are converted to photoreceptor fates.

(Lesokhin et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Egfr^{2.W15R.L24V.Scer\UAS}

Egfr^{2.W15R.L24V.UAS}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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