FB2026_02 , released June 18, 2026
Allele: Dmel\Desat27-11HD-low
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General Information
Symbol
Dmel\Desat27-11HD-low
Species
D. melanogaster
Name
FlyBase ID
FBal0095912
Feature type
allele
Associated gene
Dmel\Desat2
Associated Insertion(s)
Carried in Construct
Also Known As
Z30
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Greenberg et al., 2003, Takahashi et al., 2001, Coyne, 1998.5.14)
Progenitor genotype
Cytology
Description

Encodes a functional copy of desat2.

(Greenberg et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females produce 5,9-heptacosadiene as the predominant cuticular hydrocarbon.

      (Greenberg et al., 2003)

      Flies carrying the Z-type desat2Z allele in an M-type background have a higher 5,9-heptacosadiene to 7,11-heptacosadiene ratio than control desat2M flies (which carry the M-type allele of desat2 in an M-type background). However, the ratio is not as high as seen in natural populations of flies from Zimbabwe populations (which carry the naturally occurring desat27-11HD-low Z-type allele), indicating that there are likely other loci involved in cuticle hydrocarbon composition.

      (Greenberg et al., 2003)

      Females have a high ratio of 5,9 heptacosadiene/7,11 heptacosadiene (the "High" cuticular hydrocarbon (CH) type).

      (Takahashi et al., 2001)

      Changes the proportion of 7,11- heptacosadiene:5 ,9-heptacosadiene from high to low.

      (Coyne et al., 1999, Coyne, 1998.5.14)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Isolated from: Dominican Republic (Jaragua 3B) population, 1993. Associated with: In(3L)P.

      (Coyne, 1998.5.14)
      Comments
      Comments

      Ancestral allele. The cosmopolitan desat25-9HD-low allele is derived from the ancestral desat27-11HD-low allele and has spread worldwide.

      (Takahashi et al., 2001)

      Prevalent in African and Caribbean populations.

      (Greenberg et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      7-11HD1
      (Coyne, 1998.5.14)
      7-11HDl
      Desat27-11HD-low
      Z30
      (Coyne and Elwyn, 2006, Greenberg et al., 2003)
      Zsyn
      (Coyne and Elwyn, 2006)
      desat27-11HD-low
      Name Synonyms
      Secondary FlyBase IDs
        References (6)