FB2026_03 , released September 17, 2026
Allele: Dmel\axoP12
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General Information
Symbol
Dmel\axoP12
Species
D. melanogaster
Name
FlyBase ID
FBal0097058
Feature type
allele
Associated gene
Dmel\axo
Associated Insertion(s)
P{}axoP12
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Yuan and Ganetzky, 1999)
Progenitor genotype
Associated Insertion(s)
P{}axoP12
Cytology
Description

Insertion of a P-element 23bp upstream of the first exon.

(Yuan and Ganetzky, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes appear normal at 20o to 22oC, but become paralysed within 3 minutes at 37o to 38oC. Full recovery is seen within 7 to 8 minutes if the flies are transferred to 20o to 22oC. At 20oC, the resting membrane potential and the amplitude and duration of evoked excitatory junctional potentials (EJPs) at the neuromuscular junction are normal in axoP12 larvae. EJPs are lost within 10 minutes if the larvae are transferred to 38oC. During this interval the threshold required to evoke EJPs increases until transmission fails completely. Compound action potentials are either lost or reduced by more than 90%, in contrast to wild-type larvae, indicating a defect in axonal conduction. The EJP is fully recovered if the larvae are returned to 20oC.

      (Yuan and Ganetzky, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P-element confirms that it causes the axoP12 phenotype.

      (Yuan and Ganetzky, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      axoP12
      Name Synonyms
      Secondary FlyBase IDs
        References (1)