FB2026_03 , released September 17, 2026
Allele: Dmel\RanGAPSd.12A
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General Information
Symbol
Dmel\RanGAPSd.12A
Species
D. melanogaster
Name
FlyBase ID
FBal0097119
Feature type
allele
Associated gene
Dmel\RanGAP
Associated Insertion(s)
Carried in Construct
P{Sd12A}
Also Known As
p[(w+Sd)12A]
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Merrill et al., 1999)
Progenitor genotype
Carried in construct
P{Sd12A}
Cytology
Description

Construct: Genomic fragment containing the entire distal half of the duplication found in RanGapSD chromosomes plus approximately 500bp from the proximal half of the duplication. Two in-frame stop codons have been introduced into the Hs2st coding sequence present in this genomic fragment.

(Merrill et al., 1999)
Allele components
Component
Use(s)
Encoded product / tool
RanGAP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the absence of any upwards modifiers of RanGap, RanGapSd.12A causes only a low level of distortion.

      (Merrill et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying RanGapSd.12A show a high level of segregation distortion against target chromosomes carrying Rsps or Rspss.

      (Kusano et al., 2001)

      When RanGapSd.12A is introduced into a background containing the "SD-5Rev7" chromosome (which contains the E(SD)unspecified, Rspi, M(Sd)unspecified and St-SDunspecified components of the SD system) and an Rspss chromosome, strong distortion of the Rspss chromosome is seen. When RanGapSd.12A is introduced into a background containing the Df(2L)Sd77 chromosome (which contains the E(SD)unspecified, Rspi, M(Sd)unspecified and St-SDunspecified components of the SD system) and an Rspss chromosome, strong distortion of the Rspss chromosome is seen. Distortion of the Rspss chromosome caused by RanGapSd.12A is eliminated in the presence of the "SD-5Rev16" chromosome (which contains a Suppressor of SD, RanGapSD, E(SD)unspecified, Rspi, M(Sd)unspecified and St-SDunspecified) which is a strong suppressor of distortion.

      (Merrill et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RanGAPSd.12A
      RanGapSd.12A
      Sd12A
      Name Synonyms
      Secondary FlyBase IDs
        References (2)