FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Orc1K604E.hs
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General Information
Symbol
Dmel\Orc1K604E.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0097205
Feature type
allele
Associated gene
Dmel\Orc1
Associated Insertion(s)
Carried in Construct
P{hs-Orc1.K604E}
Key Links
Transgenic product class
missense_variant
(Asano and Wharton, 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Asano and Wharton, 1999)
Mutagen
in vitro construct
(Asano and Wharton, 1999)
Progenitor genotype
Orc1hs.PA
(Asano and Wharton, 1999)
Carried in construct
P{hs-Orc1.K604E}
Cytology
Description

Construct: Amino acid replacement: K604E. Mutation is in the conserved Walker motif.

(Asano and Wharton, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Orc1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying four copies of Orc1K604E.hs show none of the phenotypes seen in flies carrying four copies of Orc1hs.PA. In particular, DNA replication is unperturbed in stage 10B follicle cells.

      (Asano and Wharton, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Orc1K604E.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)