FlyBase Allele Report: Dmel\N[FLN.UAS]

General Information

Symbol

Dmel\N^FLN.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0097211

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.FLN}

Also Known As

UAS-FLN, UAS-N, UAS-N^FL

Key Links

Transgenic product class

wild_type

(Zecchini et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zecchini et al., 1999)

Mutagen

in vitro construct

(Zecchini et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-N.FLN}

Cytology

Description

Full length N coding region is expressed from UAS regulatory sequences.

(Zecchini et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number

(Peralta et al., 2009)

Phenotype Manifest In

embryonic epidermis | dorsal, with Scer\GAL4^da.G32

(Zecchini et al., 1999)

secondary pigment cell

(Peralta et al., 2009)

tertiary pigment cell

(Peralta et al., 2009)

Detailed Description

Statement

Reference

Expression of N^FLN.Scer\UAS in the eye under the control of Scer\GAL4^LL54 induces an excess of interommatidial pigment cells.

(Peralta et al., 2009)

When expression is driven by Scer\GAL4^da.G32, embryos develop a crinkled dorsal epidermis and, occasionally, a dorsal hole.

(Zecchini et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^LL54/N^FLN.UAS is an enhancer of increased cell death phenotype of Chc⁴

(Peralta et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^LL54/N^FLN.UAS is an enhancer of secondary pigment cell phenotype of Chc⁴

(Peralta et al., 2009)

Scer\GAL4^LL54/N^FLN.UAS is an enhancer of tertiary pigment cell phenotype of Chc⁴

(Peralta et al., 2009)

Suppressor of

Statement

Reference

N^FLN.UAS, Scer\GAL4^dpp.PU is a suppressor of wing disc | somatic clone phenotype of N^55e11, Scer\GAL4^dpp.PU, arm^{S10.UAS.Tag:MYC}

(Sanders et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of N^FLN.Scer\UAS in the eye under the control of Scer\GAL4^LL54 enhances the interommatidial cell death observed in Chc⁴ mutant eyes.

(Peralta et al., 2009)

Clones of cells mutant for N^55e11 and expressing arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^dpp.PU are smaller and more frequent when N^FLN.Scer\UAS is coexpressed.

(Sanders et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^da.G32/N^FLN.UAS rescues N^unspecified

(Zecchini et al., 1999)

Comments

Rescue of neurogenic phenotype is good in both the dorsal and ventral regions of the embryo.

(Zecchini et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^FLN.Scer\UAS

N^FLN.UAS

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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