FlyBase Allele Report: Dmel\Btk[1.hs]

General Information

Symbol

Dmel\Btk^1.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0098530

Feature type

allele

Associated gene

Dmel\Btk

Associated Insertion(s)

Carried in Construct

P{hs-Btk.1}

Key Links

Transgenic product class

cDNA

(Baba et al., 1999)

wild_type

(Baba et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Baba et al., 1999)

wild_type

(Baba et al., 1999)

Mutagen

in vitro construct

(Baba et al., 1999)

Progenitor genotype

Carried in construct

P{hs-Btk.1}

Cytology

Description

Expression of Btk29A type 1 cDNA is driven by a heat shock promoter.

(Baba et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Btk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Baba et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Btk^1.hs rescues Btk^fic-P

(Baba et al., 1999)

Partially rescues

Btk^1.hs partially rescues Btk^fic-P

(Hamada et al., 2005)

Comments

The split apodeme phenotype seen in Btk29A^fic-P males is rescued by expression of Btk29A^1.hs during the late third larval instar to pupal stage. The reduced longevity seen in Btk29A^fic-P adults is partially alleviated by expression of Btk29A^1.hs throughout the third larval instar to pupal stage.

(Hamada et al., 2005)

Heat shock during the pupal stages rescues the male genitalia morphology and mating behavior phenotypes of Btk29A^fic-P, as well as the reduced adult life span. The most effective period of heat shock for rescue of the longevity phenotype is between the last day of the third larval instar and the first day of pupation.

(Baba et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Btk29A^1.hs

Btk^1.hs

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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