FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shaVAI51
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General Information
Symbol
Dmel\shaVAI51
Species
D. melanogaster
Name
FlyBase ID
FBal0099828
Feature type
allele
Associated gene
Dmel\sha
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Adler, 1999.9.22)
Progenitor genotype
Cytology
Description

Amino acid replacement: R314S.

(Ren et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,331,812..11,331,812 [+]
Nucleotide change:

A11331812Y

Amino acid change:

R314S | sha-PA; R321S | sha-PB; R314S | sha-PC

Reported amino acid change:

R314S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ren et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      3rd posterior cell | dorsal & wing hair | supernumerary

      (Ren et al., 2006)

      adult abdomen & trichome

      (Ren et al., 2006)

      arista

      (He and Adler, 2002)

      dorsal denticle

      (Ren et al., 2006)

      mesothoracic tergum & trichome

      (Ren et al., 2006)

      wing hair | somatic clone

      (Ren et al., 2006, Bokel et al., 2005)
      Detailed Description
      Statement
      Reference

      Almost all of the cells on the dorsal surface of the centre of the E region of the wing form several small hairs in hemizygous flies. The bristles of the dorsal notum are normal in hemizygous flies, but the epidermal hairs are lost in this region. The bristles of the dorsal abdomen are also normal in hemizygous flies, but the epidermal hairs are reduced in size. Homozygous clones in the wing show a loss of hair formation.

      The dorsal denticle of the abdomen are smaller and less numerous than normal in hemizygous third instar larvae.

      (Ren et al., 2006)

      Mutant clones in the wing disrupt wing hair formation but do not result in wing blistering.

      (Bokel et al., 2005)

      Arista laterals are shorter than normal in mutant flies and are often split. The laterals can split at any time during lateral growth.

      (He and Adler, 2002)

      Homozygotes are quite weak.

      (Adler, 1999.9.22)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kojVAI51
      (He and Adler, 2002)
      shaVAI51
      (Ren et al., 2006, Bokel et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)