FlyBase Allele Report: Dmel\5-HT2A[a.Y32.hs]

General Information

Symbol

Dmel\5-HT2A^a.Y32.hs

Species

D. melanogaster

Name

antisense Y32 heat shock construct

FlyBase ID

FBal0101837

Feature type

allele

Associated gene

Dmel\5-HT2A

Associated Insertion(s)

Carried in Construct

P{hs-5-HT2A.Y32.a}

Key Links

Transgenic product class

antisense

(Colas et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

antisense

(Colas et al., 1999)

Mutagen

in vitro construct

(Colas et al., 1999)

Progenitor genotype

Carried in construct

P{hs-5-HT2A.Y32.a}

Cytology

Description

Expression of 5-HT2A cDNA including the N-terminus, the extracellular region and the first transmembrane region in the antisense orientation is driven by a heat shock promoter.

(Colas et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

5-HT2A

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Colas et al., 1999)

Phenotype Manifest In

mitotic domain 1 | extended germ band stage

(Colas et al., 1999)

primordial germ cell

(Colas et al., 1999)

ventral midline of embryo

(Colas et al., 1999)

Detailed Description

Statement

Reference

Mutant embryos show abnormal germband extension movements. There is a desynchronization between germband extension and mesodermal and endodermal invaginations, and a premature termination of movements. The ventral midline closure is often incomplete, and pole cells abnormally positioned.

(Colas et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24505

w¹¹¹⁸; P{hs-5-HT2A.Y32.a}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

5-HT2^a.Y32.hs

5-HT2A^a.Y32.hs

Name Synonyms

antisense Y32 heat shock construct

(Colas et al., 1999)

Secondary FlyBase IDs

References (1)

Report Sections

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