FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lncRNA:iab4302
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General Information
Symbol
Dmel\lncRNA:iab4302
Species
D. melanogaster
Name
FlyBase ID
FBal0102678
Feature type
allele
Associated gene
Dmel\lncRNA:iab4
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Karch et al., 1985)
Progenitor genotype
Caused by aberration
T(2;3;4)iab4302
Cytology
Description

Break lies in the iab-4 transcription unit.

(Cumberledge et al., 1990)

Mutation maps outside the 5' end of the transcription unit.

(Macias et al., 1990)

Lesion mapped to: 83-86.5 kb.

(Karch et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Germ cells are present in homozygous embryos. Some gonadal cells are present in 56% of female homozygous embryos. Gonadal cells are always associated with a cluster of germ cells in these embryos.

      (Heller and Steinmann-Zwicky, 1998)

      Gonadal precursors do not coalesce into a gonad. Pole cells are released from the stalled gonadal precursors and are scattered throughout the embryo.

      (Boyle and DiNardo, 1995)

      Defective in gonad assembly.

      (Warrior, 1994)

      Gonadogenesis is not initiated in the embryo because the mesodermal cells fail to encapsulate the pole cells in a mesodermal gonadal sheath. Formation and/or the development of male and female gonads is affected. Pole cell transplantation shows that ovary and testis formation does not require abd-A in the germ cells. Somatic chimeras demonstrated that abd-A is required in somatic cells to produce competent gonad-duct connections and in somatic cells at another site to form functional ovaries.

      (Cumberledge et al., 1992)

      Hemizygotes display a transformation of segment A4 into A3 and A2 into A3.

      (Busturia et al., 1989)

      Partial transformation of the fifth and second adult abdominal segment to the fourth or third.

      (Karch et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      R.H. Baker.

      R. Baker.

      (Karch et al., 1985)

      Induced with: abd-Aiab4-302.

      (Cumberledge et al., 1990)
      Comments
      Comments

      Mutations in iab-4 have effects on the abd-A transcription unit, so such mutations are considered to be simultaneously mutant for iab-4 and abd-A.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      iab-4302
      iab4302
      (Eberhart and Wasserman, 1995)
      iab431616.302
      lncRNA:iab4302
      Name Synonyms
      Secondary FlyBase IDs
        References (12)