FlyBase Allele Report: Dmel\Paics[1]

General Information

Symbol

Dmel\Paics¹

Species

D. melanogaster

Name

FlyBase ID

FBal0104689

Feature type

allele

Associated gene

Dmel\Paics

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(O'Donnell et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | recessive

(O'Donnell et al., 2000)

auxotroph | recessive

(O'Donnell et al., 2000)

visible | adult stage (with Df(1)ED7165)

(Schleede and Blair, 2015)

visible | adult stage (with Paics^X1)

(Schleede and Blair, 2015)

Phenotype Manifest In

pigment cell

(O'Donnell et al., 2000)

posterior crossvein (with Df(1)ED7165)

(Schleede and Blair, 2015)

posterior crossvein (with Paics^X1)

(Schleede and Blair, 2015)

presumptive wing vein | pupal stage

(Schleede and Blair, 2015)

wing disc | pupal stage

(Schleede and Blair, 2015)

Detailed Description

Statement

Reference

Paics¹ homozygous pupae show defects in posterior crossvein formation. Paics¹/Df(1)ED7165 as well as Paics¹/Paics^X1 transheterozygous adults display complete or partial loss of the wing posterior crossvein, respectively.

(Schleede and Blair, 2015)

Eye colour: homozygotes have reduced red eye pigmentation. Homozygotes show adenine auxotrophy. Homozygous females respond positively to supplementation of the medium with adenine, adenosine or RNA and do not respond to supplementation with cytidine, guanine, uridine or hypoxanthine.

(O'Donnell et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Paics²⁽⁷⁾

(O'Donnell et al., 2000)

Paics³

(O'Donnell et al., 2000)

Paics²⁽²⁵⁾

(O'Donnell et al., 2000)

Paics⁶

(O'Donnell et al., 2000)

Paics⁸

(O'Donnell et al., 2000)

Paics⁵

(O'Donnell et al., 2000)

Paics⁴

(O'Donnell et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

90986

Paics¹/FM6

Notes on Origin

Discoverer

Selected as: a recessive mutation showing reduced red eye pigmentation and adenine auxotrophy.

(O'Donnell et al., 2000)

Comments

Complements: ade4¹. Alleles can be placed in order on the basis of relative survival on standard medium (from least to most viable): ade5¹, ade4¹, ade5²⁽⁷⁾, <up>ade5⁵, ade5⁶, ade5⁸</up>.

(O'Donnell et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Paics¹

ade5¹

(Schleede and Blair, 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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