FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\BicDH4
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General Information
Symbol
Dmel\BicDH4
Species
D. melanogaster
Name
FlyBase ID
FBal0104886
Feature type
allele
Associated gene
Dmel\BicD
Associated Insertion(s)
Carried in Construct
P{BicD.H4}
Key Links
Transgenic product class
dominant_negative_variant
(Oh et al., 2000)
inframe_deletion
(Oh et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Oh et al., 2000)
inframe_deletion
(Oh et al., 2000)
Mutagen
in vitro construct
(Oh et al., 2000)
Progenitor genotype
BicD+m4
(Oh et al., 2000)
Carried in construct
P{BicD.H4}
Cytology
Description

Deletion of 133 amino acids (613-745), removing the H4 heptad repeat.

(Oh et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
BicD
Encoded product / tool
BicD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BicDH4 enhances the phenotype of BicDH2 and BicDH3, i.e. fewer eggs are laid than for BicDH2 or BicDH3 alone and more of the laid eggs are more severely ventralised.

      (Oh et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      BicDH4 fails to rescue BicDr

      (Oh et al., 2000)
      Comments

      Does not rescue the zygotic viability of BicDr5/Df(2L)TW119. Cannot rescue the female sterility defect of the hypomorphic BicDr or BicDR26, even when present in two copies. Cannot rescue the germline clone oocyte development phenotype of null BicD alleles.

      (Oh et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bic-DH4
      (Oh and Steward, 2001)
      BicDH4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)