FB2026_02 , released June 18, 2026
Allele: Dmel\ftzVP16.hs
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General Information
Symbol
Dmel\ftzVP16.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0117508
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

An Hsp70 promoter drives expression of ftz amino acids 3 to 337 fused to the VP16 activation domain.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ftzhs.T:Hsim\VP16 during embryogenesis using heat shock results in a decrease in the number of wild-type cuticles, with the maximum decrease centered at a time of heat shock of about 2.5 hours after egg laying (AEL). ftzhs.T:Hsim\VP16 is able to induce patterning defects with a modest increase in efficiency at both earlier and later stages of development compared to ftz3-413.hs. The most common phenotype induced by ftzhs.T:Hsim\VP16 is the "anti-ftz" pair rule phenotype; deletion of ftz-independent parasegments. ftzhs.T:Hsim\VP16 also induces other cuticle phenotypes. The first is characterised by fusions between alternate denticle belts. Most of these fusions (approximately 80%) occur in posterior regions. Disruptions of terminal structures are also seen in these cuticles. This phenotype peaks when heat pulses are given between 1 hour 40 minutes and 2 hours 20 minutes AEL. The second cuticle phenotype is an extreme pair-wise fusion of denticle belts with the remaining denticles arranged in mirror-image symmetry. This phenotype peaks with a frequency of about 15% when heat pulses are given between 2 hours 40 minutes to 3 hours 10 minutes AEL. The third phenotype is deletions of both naked and denticle-belt containing portions of each segment. The remaining portions of each denticle belt appear to be duplicated with mirror image symmetry. This phenotype is prevalent when heat pulses are given between 3 hours to 3 hours 30 minutes AEL. The final phenotype is a deletion of all denticle belts. This occurs when heat pulses are given between 3 hours 30 minutes to 4 hours AEL.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ftzVP16.hs
ftzhs.T:Hsim\VP16
Name Synonyms
Secondary FlyBase IDs
    References (1)