FlyBase Allele Report: Mmus\Map3k7[GMR.PT]

General Information

Symbol

Mmus\Map3k7^GMR.PT

Species

M. musculus

Name

glass multimer reporter construct of Takatsu

FlyBase ID

FBal0117704

Feature type

allele

Associated gene

Mmus\Map3k7

Associated Insertion(s)

Carried in Construct

P{GMR-mTAK1}

Transgenic product class

cDNA

(Takatsu et al., 2000)

wild_type

(Takatsu et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Takatsu et al., 2000)

wild_type

(Takatsu et al., 2000)

Mutagen

in vitro construct

(Takatsu et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-mTAK1}

Cytology

Description

The full length Mmus\Map3k7 cDNA is expressed under the control of GMR regulatory sequences.

(Takatsu et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Mmus\Map3k7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cone cell | P-stage

(Takatsu et al., 2000)

eye

(Takatsu et al., 2000)

eye photoreceptor cell

(Takatsu et al., 2000)

ommatidium

(Takatsu et al., 2000)

photoreceptor cell pigment granule

(Takatsu et al., 2000)

primary pigment cell

(Takatsu et al., 2000)

secondary pigment cell

(Takatsu et al., 2000)

tertiary pigment cell

(Takatsu et al., 2000)

Detailed Description

Statement

Reference

Expression of Mmus\Tak1^GMR.PT in the eye produces relatively weak defects in the compound eye. About half of mutant flies have a rough eye phenotype and a reduction in the size of the eye, many ommatidia typically in the medial region are fused to each other. Some of these ommatidia are missing photoreceptors, while others show disrupted rows of pigment granules. In the pupal eye disc, only two or three (as opposed to 4 in wild-type) cone cells are observed. The number of primary pigment cells are relatively normal, but occasionally one of these are also missing. Secondary and tertiary pigment cells are rarely seen in mutant retina.

(Takatsu et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mmus\Map3k7^GMR.PT has visible phenotype, enhanceable by Hsap\TAB1^GMR.PT

(Takatsu et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mmus\Map3k7^GMR.PT has eye phenotype, enhanceable by Hsap\TAB1^GMR.PT

(Takatsu et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mmus\Map3k7^GMR.PT

Mmus\Tak1^GMR.PT

Name Synonyms

glass multimer reporter construct of Takatsu

(Takatsu et al., 2000)

Secondary FlyBase IDs

References (1)

Report Sections

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