FB2026_02 , released June 18, 2026
Allele: Dmel\pimg.dba.Tag:MYC
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General Information
Symbol
Dmel\pimg.dba.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0118072
Feature type
allele
Associated gene
Dmel\pim
Associated Insertion(s)
Carried in Construct
P{gpimdba-myc}
Also Known As
gpimdba-myc
Key Links
Transgenic product class
missense_variant
(Leismann et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Leismann et al., 2000)
Mutagen
in vitro construct
(Leismann et al., 2000)
Progenitor genotype
Carried in construct
P{gpimdba-myc}
Cytology
Description

The pim regulatory region drives expression of pim with a mutated destruction box (KKPLGNLDN changed to AKPAGNLDA).

(Leismann et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
pim
Encoded product / tool
pim
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A single copy of P{gpimdba-myc} is tolerated in a pim+ background. However, two copies of P{gpimdba-myc} result in complete lethality (5 out of 8 lines) or severe morphological abnormalities (rough eyes, notched wings, sterility) in rare escapers (3 out of 8 lines). These phenotypes are not caused by transgene insertion position effects.

      (Leismann et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The CNS of stage 14 poloS132408 homozygous embryos carrying pimg.dba.T:Hsap\MYC contains many abnormal cells with very large polyploid nuclei.

      (Leismann and Lehner, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      pimg.dba.Tag:MYC fails to rescue pimIL

      (Leismann et al., 2000)
      Comments

      The addition of pimg.dba.T:Hsap\MYC to pimIL animals does not affect sister chromatid separation, however about 10% of metaphase figures had chromatin bridges. The addition of pimg.dba.T:Hsap\MYC does not rescue the lethality seen in pimIL homozygotes.

      (Leismann et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pimg.dba.T:Hsap\MYC
      pimg.dba.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)