FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fwd5
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General Information
Symbol
Dmel\fwd5
Species
D. melanogaster
Name
FlyBase ID
FBal0119250
Feature type
allele
Associated gene
Dmel\fwd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Brill et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: S1138F.

(Brill et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:307,144..307,144 [-]
Nucleotide change:

C307144T

Amino acid change:

S1474F | fwd-PA; S1474F | fwd-PB; S1138F | fwd-PC; S1474F | fwd-PD; S1474F | fwd-PE

Reported amino acid change:

S1138F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Brill et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      spermatid & nucleus (with Df(3L)7C)

      (Brill et al., 2000)
      Detailed Description
      Statement
      Reference

      99.8% of spermatids in the testes of fwd5/Df(3L)7C males are defective, being derived from one or more defective meiotic and/or mitotic divisions. Spermatids with 4 nuclei per mitochondrial derivative are often seen, and spermatids with 2, 3, 6, 8, 12 or 16 nuclei per mitochondrial derivative are also sometimes seen.

      (Brill et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fwd5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)