FB2026_02 , released June 18, 2026
Allele: Dmel\Syx1AL247
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General Information
Symbol
Dmel\Syx1AL247
Species
D. melanogaster
Name
FlyBase ID
FBal0120321
Feature type
allele
Associated gene
Dmel\Syx1A
Associated Insertion(s)
P{lacZ}Syx1AL247
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Stewart et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{lacZ}Syx1AL247
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Syx1AL247/Syx1AL2 third instar larvae have a normal number of varicosities at the neuromuscular junction of muscle fibres 6 and 7 and synaptic proliferation at the neuromuscular junction is normal.

      (Rieckhof et al., 2003)

      A reduction is seen in EJCs in Syx1AL2/Syx1AL247 larvae over a full range of Ca2+ concentrations. Sensitivity to Calcium is not altered. There are no differences in mEJC amplitude that can explain the observed reduction in synaptic transmission, but a reduction in mEJC frequency is seen. A reduction in Ca2+ cooperativity of synaptic transmission is seen. The mean mEJC decay time is not affected.

      (Stewart et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Syx1AL247
      syx1AL247
      (Stewart et al., 2000)
      syxL247
      (Rieckhof et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)