FB2026_03 , released September 17, 2026
Allele: Dmel\I-elementgagRZI.as.Act5C
Open Close
General Information
Symbol
Dmel\I-element\gagRZI.as.Act5C
Species
D. melanogaster
Name
antisense construct
FlyBase ID
FBal0120803
Feature type
allele
Associated gene
I-element\gag
Associated Insertion(s)
Carried in Construct
P{I-element\gag.RZI}
Key Links
Transgenic product class
antisense
(Gauthier et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
antisense
(Gauthier et al., 2000)
Mutagen
in vitro construct
(Gauthier et al., 2000)
Progenitor genotype
Carried in construct
P{I-element\gag.RZI}
Cytology
Description

Construct: An Act5C promoter drives expression of part of I-element\gag (from +1 to +1104bp) in antisense orientation.

(Gauthier et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Act5C
Encoded product / tool
I-element\gag
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      P{I-element\gag.RZI} decreases the intensity of the female sterile phenotype that is normally seen in the female progeny of a cross of inducer (I) males with reactive (R) females. There is a correlation between the copy number of P{I-element\gag.RZI} and the decrease in the sterility level. In addition to this zygotic repressive effect, the P{I-element\gag.RZI} transgene also induces maternal and paternal repressive effects when introduced into flies. After introducing the transgene into reactive (R) females, then allowing maternal transmission of the transgenes over several generations, followed by crossing with inducer (I) males, transgenic females show a full reversion of the sterility phenotype as early as the first day of egg laying. This maternal effect is a quantitative effector that accumulates over generations. Zygotic and maternal effects increase with the number of P{I-element\gag.RZI} copies.

      (Gauthier et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      I-element\gagRZI.as.Act5C
      Name Synonyms
      antisense construct
      (Gauthier et al., 2000)
      Secondary FlyBase IDs
        References (1)